Assay Detail
Binding
CHEMBL659585
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Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
CCK peptides with combined features of hexa- and tetrapeptide CCK-A agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.99 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.39 |
| CHEMBL3142373 | — | — | 1 | 7.44 |
| CHEMBL2369815 | — | — | 1 | 7.08 |
| CHEMBL3143672 | — | — | 1 | 6.91 |
| CHEMBL2369817 | — | — | 1 | 6.82 |
| CHEMBL3142366 | — | — | 1 | 6.70 |
| CHEMBL76248 | — | — | 1 | 6.65 |
| CHEMBL323521 | — | — | 1 | 6.60 |
| CHEMBL320868 | — | — | 1 | 6.24 |
| CHEMBL2369816 | — | — | 1 | 6.02 |
| CHEMBL2115177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL3142373 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2369815 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL3143672 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL2369817 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3142366 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL76248 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL323521 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL320868 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL2369816 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL2115177 | — | Ki | > | 1000.0 | nM | - |