Assay Detail
Binding
CHEMBL659586
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Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.24 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411271 | — | — | 1 | 9.51 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.22 |
| CHEMBL262197 | — | — | 1 | 9.12 |
| CHEMBL333477 | — | — | 1 | 8.59 |
| CHEMBL64605 | — | — | 1 | 8.03 |
| CHEMBL177799 | — | — | 1 | 7.75 |
| CHEMBL120632 | TETRAGASTRIN | -1.0 | 1 | 7.03 |
| CHEMBL408389 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411271 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL1121 | SINCALIDE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL262197 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL333477 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL64605 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL177799 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL120632 | TETRAGASTRIN | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL408389 | — | Ki | = | 198.0 | nM | 6.70 |