Assay Detail
Binding
CHEMBL659692
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Binding to Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat CB1.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.26 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111724 | — | — | 1 | 10.00 |
| CHEMBL432107 | — | — | 1 | 10.00 |
| CHEMBL111148 | — | — | 1 | 9.62 |
| CHEMBL109393 | — | — | 1 | 8.70 |
| CHEMBL111340 | — | — | 1 | 8.21 |
| CHEMBL111099 | — | — | 1 | 7.59 |
| CHEMBL320408 | — | — | 1 | 7.49 |
| CHEMBL113230 | — | — | 1 | 7.49 |
| CHEMBL109972 | — | — | 1 | 7.42 |
| CHEMBL111702 | — | — | 1 | 7.30 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111724 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL432107 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL111148 | — | Ki | = | 0.241 | nM | 9.62 |
| CHEMBL109393 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL111340 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL111099 | — | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL320408 | — | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL113230 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL109972 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL111702 | — | Ki | = | 49.8 | nM | 7.30 |
| CHEMBL465 | DRONABINOL | Ki | = | 80.3 | nM | 7.09 |