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Assay Detail

CHEMBL659694

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cannabinoid receptor 1 (CHEMBL3571)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
Khanolkar AD, Abadji V, Lin S, Hill WA, Taha G, Abouzid K, Meng Z, Fan P, Makriyannis A.
J Med Chem (1996) 39 : 4515 -4519
PubMed 8893848 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.28 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL120526 METHANANDAMIDE 1 7.70
CHEMBL15848 ANANDAMIDE 1 7.11
CHEMBL15948 1 6.76
CHEMBL343975 1 6.69
CHEMBL434069 1 6.66
CHEMBL141463 1 6.44
CHEMBL342659 1 5.86
CHEMBL141647 1 5.81
CHEMBL137899 1 5.78
CHEMBL140773 1 5.77
CHEMBL39878 1 5.75
CHEMBL142066 1 5.66
CHEMBL139037 1 5.61
CHEMBL141456 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL120526 METHANANDAMIDE Ki = 20.0 nM 7.70
CHEMBL15848 ANANDAMIDE Ki = 78.0 nM 7.11
CHEMBL15948 Ki = 174.0 nM 6.76
CHEMBL343975 Ki = 203.0 nM 6.69
CHEMBL434069 Ki = 217.0 nM 6.66
CHEMBL141463 Ki = 363.0 nM 6.44
CHEMBL342659 Ki = 1380.0 nM 5.86
CHEMBL141647 Ki = 1560.0 nM 5.81
CHEMBL137899 Ki = 1660.0 nM 5.78
CHEMBL140773 Ki = 1690.0 nM 5.77
CHEMBL39878 Ki = 1760.0 nM 5.75
CHEMBL142066 Ki = 2200.0 nM 5.66
CHEMBL139037 Ki = 2460.0 nM 5.61
CHEMBL141456 Ki > 3000.0 nM -