Assay Detail
Binding
CHEMBL659695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55940 binding to Cannabinoid receptor 1 in rat brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.43 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131627 | — | — | 1 | 9.96 |
| CHEMBL307696 | — | — | 1 | 9.64 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 7.66 |
| CHEMBL334533 | DEXANABINOL | 3.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131627 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL307696 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL15848 | ANANDAMIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL334533 | DEXANABINOL | Ki | = | 360.0 | nM | 6.44 |