Assay Detail
Binding
CHEMBL659791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibitory activity against human heart chymase (HHC)
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.41 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353816 | — | — | 1 | 8.89 |
| CHEMBL170200 | — | — | 1 | 8.51 |
| CHEMBL287318 | — | — | 1 | 8.25 |
| CHEMBL170878 | — | — | 1 | 8.20 |
| CHEMBL170718 | — | — | 1 | 8.19 |
| CHEMBL170879 | — | — | 1 | 8.17 |
| CHEMBL170838 | — | — | 1 | 8.15 |
| CHEMBL170074 | — | — | 2 | 8.13 |
| CHEMBL172873 | — | — | 1 | 7.90 |
| CHEMBL171676 | — | — | 1 | 7.88 |
| CHEMBL352917 | — | — | 1 | 7.79 |
| CHEMBL171801 | — | — | 1 | 7.78 |
| CHEMBL171119 | — | — | 1 | 7.74 |
| CHEMBL173989 | — | — | 1 | 7.62 |
| CHEMBL170683 | — | — | 1 | 7.54 |
| CHEMBL369796 | — | — | 1 | 7.52 |
| CHEMBL170402 | — | — | 1 | 7.44 |
| CHEMBL147013 | — | — | 1 | 7.25 |
| CHEMBL171805 | — | — | 1 | 7.18 |
| CHEMBL171492 | — | — | 1 | 7.15 |
| CHEMBL368262 | — | — | 1 | 6.31 |
| CHEMBL171354 | — | — | 1 | 6.29 |
| CHEMBL172849 | — | — | 1 | 6.00 |
| CHEMBL368502 | — | — | 1 | 5.98 |
| CHEMBL355609 | — | — | 1 | 5.81 |
| CHEMBL172078 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353816 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL170200 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL287318 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL170878 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL170718 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL170879 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL170838 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL170074 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL172873 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL171676 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL352917 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL171801 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL171119 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL173989 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL170683 | — | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL369796 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL170402 | — | Ki | = | 36.4 | nM | 7.44 |
| CHEMBL147013 | — | Ki | = | 55.8 | nM | 7.25 |
| CHEMBL171805 | — | Ki | = | 65.6 | nM | 7.18 |
| CHEMBL171492 | — | Ki | = | 70.1 | nM | 7.15 |
| CHEMBL170074 | — | Ki | = | 92.4 | nM | 7.03 |
| CHEMBL368262 | — | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL171354 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL172849 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL368502 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL355609 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL172078 | — | Ki | = | 3620.0 | nM | 5.44 |