Assay Detail
Binding
CHEMBL659792
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Compound was evaluated for inhibitory activity against human heart chymase (HHC)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.97 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355430 | — | — | 1 | 8.52 |
| CHEMBL436061 | — | — | 1 | 8.41 |
| CHEMBL169707 | — | — | 1 | 8.25 |
| CHEMBL355132 | — | — | 1 | 8.22 |
| CHEMBL170697 | — | — | 1 | 8.17 |
| CHEMBL170152 | — | — | 1 | 7.85 |
| CHEMBL366721 | — | — | 1 | 7.68 |
| CHEMBL433799 | — | — | 1 | 7.64 |
| CHEMBL171769 | — | — | 1 | 7.56 |
| CHEMBL367094 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355430 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL436061 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL169707 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL355132 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL170697 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL170152 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL366721 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL433799 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL171769 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL367094 | — | Ki | = | 36.6 | nM | 7.44 |