Assay Detail
Binding
CHEMBL659816
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Compound was tested for its inhibitory activity against cathepsin B
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.05 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418606 | — | — | 1 | 7.75 |
| CHEMBL430922 | — | — | 1 | 7.35 |
| CHEMBL36801 | — | — | 1 | 7.16 |
| CHEMBL36146 | — | — | 1 | 7.07 |
| CHEMBL36904 | — | — | 1 | 7.01 |
| CHEMBL191881 | LEUPEPTIN | — | 1 | 6.93 |
| CHEMBL36969 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418606 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL430922 | — | IC50 | = | 45.1 | nM | 7.35 |
| CHEMBL36801 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL36146 | — | IC50 | = | 85.1 | nM | 7.07 |
| CHEMBL36904 | — | IC50 | = | 97.7 | nM | 7.01 |
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL36969 | — | IC50 | = | 836.0 | nM | 6.08 |