Assay Detail
Binding
CHEMBL659851
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Dissociation constant was reported against Carbonic anhydrase II
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.82 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333281 | — | — | 1 | 9.36 |
| CHEMBL417975 | SEZOLAMIDE | 2.0 | 1 | 9.20 |
| CHEMBL333520 | — | — | 1 | 8.96 |
| CHEMBL120418 | — | — | 1 | 8.94 |
| CHEMBL105080 | — | — | 1 | 8.91 |
| CHEMBL475 | N-DESETHYL DORZOLAMIDE | — | 1 | 8.82 |
| CHEMBL120046 | — | — | 1 | 8.80 |
| CHEMBL273822 | — | — | 1 | 8.73 |
| CHEMBL67511 | TRIFLUOROMETHANESULFONAMIDE | — | 1 | 8.70 |
| CHEMBL333193 | — | — | 1 | 8.48 |
| CHEMBL421060 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333281 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL417975 | SEZOLAMIDE | Ki | = | 0.635 | nM | 9.20 |
| CHEMBL333520 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL120418 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL105080 | — | Ki | = | 1.24 | nM | 8.91 |
| CHEMBL475 | N-DESETHYL DORZOLAMIDE | Ki | = | 1.52 | nM | 8.82 |
| CHEMBL120046 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL273822 | — | Ki | = | 1.88 | nM | 8.73 |
| CHEMBL67511 | TRIFLUOROMETHANESULFONAMIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL333193 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL421060 | — | Ki | = | 7.0 | nM | 8.15 |