Assay Detail
Binding
CHEMBL659852
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In vitro binding to human erythrocyte Carbonic anhydrase II was determined by fluorescence competition assay employing the fluorescent CA inhibitor dansylamide
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.03 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120418 | — | — | 1 | 8.94 |
| CHEMBL158261 | — | — | 1 | 8.44 |
| CHEMBL314569 | — | — | 1 | 8.08 |
| CHEMBL158090 | — | — | 1 | 7.85 |
| CHEMBL352218 | — | — | 1 | 7.85 |
| CHEMBL158026 | — | — | 1 | 7.55 |
| CHEMBL347369 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120418 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL158261 | — | Ki | = | 3.63 | nM | 8.44 |
| CHEMBL314569 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL158090 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL352218 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL158026 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL347369 | — | Ki | = | 30.5 | nM | 7.52 |