Assay Detail
Binding
CHEMBL659853
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In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dansylamide
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.89 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 9.31 |
| CHEMBL333193 | — | — | 1 | 8.48 |
| CHEMBL2092886 | — | — | 1 | 8.17 |
| CHEMBL348573 | — | — | 1 | 8.15 |
| CHEMBL1788205 | — | — | 1 | 7.81 |
| CHEMBL155420 | — | — | 1 | 7.74 |
| CHEMBL158363 | — | — | 1 | 6.98 |
| CHEMBL155152 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL333193 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2092886 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL348573 | — | Ki | = | 7.11 | nM | 8.15 |
| CHEMBL1788205 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL155420 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL158363 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL155152 | — | Ki | = | 309.0 | nM | 6.51 |