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Assay Detail

CHEMBL659932

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against CCRA enzyme
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Metallo-beta-lactamase type 2 (CHEMBL4840)
Type SINGLE PROTEIN
Organism Bacteroides fragilis

Publication

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.
Sandanayaka VP, Feigelson GB, Prashad AS, Yang Y, Petersen PJ.
Bioorg Med Chem Lett (2001) 11 : 997 -1000
PubMed 11327608 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.24 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6221 1 5.85
CHEMBL267863 1 5.75
CHEMBL6281 1 5.68
CHEMBL6311 1 5.52
CHEMBL267626 1 5.51
CHEMBL6292 1 5.39
CHEMBL6261 1 4.66
CHEMBL263882 1 4.62
CHEMBL6301 1 4.15
CHEMBL267627 1 -
CHEMBL403 SULBACTAM 4.0 1 -
CHEMBL6220 1 -
CHEMBL404 TAZOBACTAM 4.0 1 -
CHEMBL6309 1 -
CHEMBL6286 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6221 IC50 = 1400.0 nM 5.85
CHEMBL267863 IC50 = 1800.0 nM 5.75
CHEMBL6281 IC50 = 2100.0 nM 5.68
CHEMBL6311 IC50 = 3000.0 nM 5.52
CHEMBL267626 IC50 = 3100.0 nM 5.51
CHEMBL6292 IC50 = 4100.0 nM 5.39
CHEMBL6261 IC50 = 22000.0 nM 4.66
CHEMBL263882 IC50 = 24000.0 nM 4.62
CHEMBL6301 IC50 = 71000.0 nM 4.15
CHEMBL267627 IC50 > 100000.0 nM -
CHEMBL403 SULBACTAM IC50 > 100000.0 nM -
CHEMBL6220 IC50 > 100000.0 nM -
CHEMBL404 TAZOBACTAM IC50 > 100000.0 nM -
CHEMBL6309 IC50 > 100000.0 nM -
CHEMBL6286 IC50 > 100000.0 nM -