Assay Detail
Binding
CHEMBL660241
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Inhibition of human neutrophil collagenase (HNC), MMP-8
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85806 | — | — | 1 | 8.70 |
| CHEMBL87229 | — | — | 1 | 8.70 |
| CHEMBL85766 | — | — | 1 | 8.70 |
| CHEMBL11306 | — | — | 1 | 8.70 |
| CHEMBL87046 | — | — | 1 | 8.40 |
| CHEMBL86468 | — | — | 1 | 8.15 |
| CHEMBL313356 | — | — | 1 | 7.92 |
| CHEMBL430838 | — | — | 1 | 7.52 |
| CHEMBL86797 | — | — | 1 | 7.50 |
| CHEMBL85933 | — | — | 1 | 6.57 |
| CHEMBL313483 | — | — | 1 | - |
| CHEMBL410259 | — | — | 1 | - |
| CHEMBL59023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85806 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL87229 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL85766 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL11306 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL87046 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL86468 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL313356 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL430838 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL86797 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL85933 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL313483 | — | Ki | < | 1.0 | nM | - |
| CHEMBL410259 | — | Ki | < | 2.0 | nM | - |
| CHEMBL59023 | — | Ki | < | 2.0 | nM | - |