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Assay Detail

CHEMBL660276

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Binding
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

C-C chemokine receptor type 1 (CHEMBL2413)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
De Lucca GV, Kim UT, Johnson C, Vargo BJ, Welch PK, Covington M, Davies P, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS.
J Med Chem (2002) 45 : 3794 -3804
PubMed 12166951 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 6.51 7.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL124127 1 7.51
CHEMBL340797 1 7.17
CHEMBL435812 1 7.15
CHEMBL341306 1 6.90
CHEMBL332277 1 6.78
CHEMBL126978 1 6.62
CHEMBL333422 1 6.53
CHEMBL333063 1 6.51
CHEMBL339752 1 6.44
CHEMBL124585 1 6.30
CHEMBL34166 BERLEX COMPOUND 1 6.20
CHEMBL125111 1 6.12
CHEMBL124084 1 6.11
CHEMBL333865 1 6.05
CHEMBL340491 1 5.87
CHEMBL338624 1 5.85
CHEMBL276784 1 -
CHEMBL127395 1 -
CHEMBL124321 1 -
CHEMBL125325 1 -
CHEMBL123791 1 -
CHEMBL123622 1 -
CHEMBL124134 1 -
CHEMBL124457 1 -
CHEMBL125618 1 -
CHEMBL124808 1 -
CHEMBL442210 1 -
CHEMBL125132 1 -
CHEMBL421634 1 -
CHEMBL124390 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL124127 IC50 = 31.0 nM 7.51
CHEMBL340797 IC50 = 67.0 nM 7.17
CHEMBL435812 IC50 = 71.0 nM 7.15
CHEMBL341306 IC50 = 125.0 nM 6.90
CHEMBL332277 IC50 = 167.0 nM 6.78
CHEMBL126978 IC50 = 240.0 nM 6.62
CHEMBL333422 IC50 = 295.0 nM 6.53
CHEMBL333063 IC50 = 310.0 nM 6.51
CHEMBL339752 IC50 = 360.0 nM 6.44
CHEMBL124585 IC50 = 500.0 nM 6.30
CHEMBL34166 BERLEX COMPOUND IC50 = 630.0 nM 6.20
CHEMBL125111 IC50 = 760.0 nM 6.12
CHEMBL124084 IC50 = 780.0 nM 6.11
CHEMBL333865 IC50 = 890.0 nM 6.05
CHEMBL340491 IC50 = 1340.0 nM 5.87
CHEMBL338624 IC50 = 1410.0 nM 5.85
CHEMBL339349 IC50 < 780.0 nM -
CHEMBL123585 IC50 > 10000.0 nM -
CHEMBL18222 IC50 > 50000.0 nM -
CHEMBL331634 IC50 > 10000.0 nM -
CHEMBL125026 IC50 > 10000.0 nM -
CHEMBL125753 IC50 < 780.0 nM -
CHEMBL340080 IC50 > 10000.0 nM -
CHEMBL125108 IC50 > 50000.0 nM -
CHEMBL124583 IC50 > 50000.0 nM -
CHEMBL123511 IC50 > 10000.0 nM -
CHEMBL338543 IC50 > 10000.0 nM -
CHEMBL124390 IC50 > 10000.0 nM -
CHEMBL421634 IC50 > 10000.0 nM -
CHEMBL125132 IC50 > 10000.0 nM -
CHEMBL442210 IC50 > 10000.0 nM -
CHEMBL124808 IC50 > 50000.0 nM -
CHEMBL125618 IC50 < 780.0 nM -
CHEMBL124457 IC50 > 50000.0 nM -
CHEMBL124134 IC50 > 10000.0 nM -
CHEMBL123622 IC50 < 780.0 nM -
CHEMBL123791 IC50 > 10000.0 nM -
CHEMBL125325 IC50 > 50000.0 nM -
CHEMBL124321 IC50 > 10000.0 nM -
CHEMBL127395 IC50 > 50000.0 nM -
CHEMBL276784 IC50 > 50000.0 nM -