Assay Detail
Binding
CHEMBL660359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.53 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421438 | — | — | 1 | 6.10 |
| CHEMBL123852 | — | — | 1 | 5.70 |
| CHEMBL124822 | — | — | 1 | 5.66 |
| CHEMBL124396 | — | — | 1 | 5.09 |
| CHEMBL125874 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421438 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL123852 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL124822 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL124396 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL125874 | — | IC50 | = | 8300.0 | nM | 5.08 |