Assay Detail
Functional
CHEMBL660367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.75 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262197 | — | — | 1 | 9.40 |
| CHEMBL120150 | — | — | 1 | 9.25 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.20 |
| CHEMBL64605 | — | — | 1 | 9.00 |
| CHEMBL120632 | TETRAGASTRIN | -1.0 | 1 | 8.85 |
| CHEMBL100538 | — | — | 1 | 8.82 |
| CHEMBL333477 | — | — | 1 | 8.82 |
| CHEMBL331394 | — | — | 1 | 8.79 |
| CHEMBL321456 | — | — | 1 | 8.70 |
| CHEMBL120827 | — | — | 1 | 8.48 |
| CHEMBL411271 | — | — | 1 | 8.47 |
| CHEMBL177799 | — | — | 1 | 8.15 |
| CHEMBL408389 | — | — | 1 | 7.77 |
| CHEMBL120335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262197 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL120150 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1121 | SINCALIDE | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL64605 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL120632 | TETRAGASTRIN | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL100538 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL333477 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL331394 | — | EC50 | = | 1.64 | nM | 8.79 |
| CHEMBL321456 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL120827 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL411271 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL177799 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL408389 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL120335 | — | EC50 | = | - | nM | - |