Assay Detail
Binding
CHEMBL660460
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Tested for inhibitory activity against bovine pancreatic chymotrypsinogen
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.86 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11391 | — | — | 1 | 7.26 |
| CHEMBL113261 | — | — | 1 | 6.30 |
| CHEMBL432442 | — | — | 1 | 6.14 |
| CHEMBL326616 | — | — | 1 | 5.24 |
| CHEMBL107291 | — | — | 1 | 5.21 |
| CHEMBL109852 | — | — | 1 | 5.02 |
| CHEMBL13684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11391 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL113261 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL432442 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL326616 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL107291 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL109852 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL13684 | — | Ki | = | 330000.0 | nM | - |