Assay Detail
Binding
CHEMBL660506
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Binding affinity at CCR was determined by displacement of [3H]OXO-M from rat brain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274524 | — | — | 1 | 5.10 |
| CHEMBL10096 | — | — | 1 | - |
| CHEMBL274525 | ABT-418 | — | 1 | - |
| CHEMBL9732 | R-NICOTINE | — | 1 | - |
| CHEMBL3 | NICOTINE | 4.0 | 1 | - |
| CHEMBL264213 | — | — | 1 | - |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | - |
| CHEMBL268750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274524 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL10096 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL274525 | ABT-418 | Ki | > | 20000.0 | nM | - |
| CHEMBL9732 | R-NICOTINE | Ki | > | 20000.0 | nM | - |
| CHEMBL3 | NICOTINE | Ki | > | 20000.0 | nM | - |
| CHEMBL264213 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL6200 | NORNICOTINE | Ki | > | 20000.0 | nM | - |
| CHEMBL268750 | — | Ki | > | 20000.0 | nM | - |