Assay Detail
Binding
CHEMBL660508
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Binding affinity at CCR was determined by displacement of [3H]nicotine from rat brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.75 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.85 |
| CHEMBL9732 | R-NICOTINE | — | 1 | 7.50 |
| CHEMBL264213 | — | — | 1 | 7.39 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL9732 | R-NICOTINE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL264213 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL6200 | NORNICOTINE | Ki | = | 56.0 | nM | 7.25 |