Assay Detail
Binding
CHEMBL660536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against dihydropteroic acid synthase (SYN) from Mycobacterium lufu (DDS sensitive)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium lufu |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.41 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48396 | ACEDIASULFONE | 2.0 | 1 | 6.06 |
| CHEMBL1043 | DAPSONE | 4.0 | 1 | 5.92 |
| CHEMBL353260 | — | — | 1 | 5.89 |
| CHEMBL143174 | — | — | 1 | 5.82 |
| CHEMBL139596 | — | — | 1 | 5.75 |
| CHEMBL352594 | — | — | 1 | 5.65 |
| CHEMBL358252 | — | — | 1 | 5.56 |
| CHEMBL143106 | — | — | 1 | 5.44 |
| CHEMBL1246 | MONO-N-ACETYL DAPSONE | — | 1 | 5.15 |
| CHEMBL143754 | — | — | 1 | 5.12 |
| CHEMBL142844 | — | — | 1 | 5.09 |
| CHEMBL140585 | — | — | 1 | 4.93 |
| CHEMBL357499 | — | — | 1 | 4.92 |
| CHEMBL172231 | — | — | 1 | 4.90 |
| CHEMBL140629 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48396 | ACEDIASULFONE | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1043 | DAPSONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL353260 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL143174 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL139596 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL352594 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL358252 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL143106 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1246 | MONO-N-ACETYL DAPSONE | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL143754 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL142844 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL140585 | — | IC50 | = | 11750.0 | nM | 4.93 |
| CHEMBL357499 | — | IC50 | = | 12060.0 | nM | 4.92 |
| CHEMBL172231 | — | IC50 | = | 12720.0 | nM | 4.90 |
| CHEMBL140629 | — | IC50 | = | 12990.0 | nM | 4.89 |