Assay Detail
Functional
CHEMBL660572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]thymidine into cellular DNA of human colorectal cells (COLO 205)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.37 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.27 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 1 | 8.18 |
| CHEMBL405532 | — | — | 1 | 6.70 |
| CHEMBL3215387 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL405532 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3215387 | — | IC50 | = | 460.0 | nM | 6.34 |