Assay Detail
Binding
CHEMBL660744
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Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from rat liver
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274185 | LECIMIBIDE | 2.0 | 1 | 8.00 |
| CHEMBL127304 | — | — | 1 | 7.96 |
| CHEMBL340487 | — | — | 1 | 7.85 |
| CHEMBL264816 | — | — | 1 | 7.62 |
| CHEMBL33780 | — | — | 1 | 7.60 |
| CHEMBL127928 | — | — | 1 | 7.42 |
| CHEMBL333544 | — | — | 1 | 7.36 |
| CHEMBL330794 | — | — | 1 | 7.32 |
| CHEMBL333228 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274185 | LECIMIBIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL127304 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL340487 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL264816 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL33780 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL127928 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL333544 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL330794 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL333228 | — | IC50 | = | 50.0 | nM | 7.30 |