Assay Detail
Binding
CHEMBL660783
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In vitro inhibition of Cyclin-dependent kinase 2 was determined.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.67 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101119 | — | — | 1 | 6.00 |
| CHEMBL421583 | — | — | 1 | 5.52 |
| CHEMBL317378 | — | — | 1 | 5.30 |
| CHEMBL100945 | — | — | 1 | 4.72 |
| CHEMBL322640 | — | — | 1 | 4.66 |
| CHEMBL99699 | — | — | 1 | 4.62 |
| CHEMBL316887 | — | — | 1 | 4.60 |
| CHEMBL100811 | — | — | 1 | 4.55 |
| CHEMBL101557 | — | — | 1 | 4.46 |
| CHEMBL101558 | — | — | 1 | 4.42 |
| CHEMBL418793 | — | — | 1 | 4.41 |
| CHEMBL101868 | — | — | 1 | 4.07 |
| CHEMBL317281 | — | — | 1 | 4.03 |
| CHEMBL99647 | — | — | 1 | 4.02 |
| CHEMBL318188 | — | — | 1 | - |
| CHEMBL316809 | — | — | 1 | - |
| CHEMBL318485 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101119 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL421583 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL317378 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL100945 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL322640 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL99699 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL316887 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL100811 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL101557 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL101558 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL418793 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL101868 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL317281 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL99647 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL318188 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL316809 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL318485 | — | IC50 | > | 100000.0 | nM | - |