Assay Detail
Binding
CHEMBL660784
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Inhibitory concentration against cyclin-dependent kinase 2
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.16 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419720 | — | — | 1 | 6.70 |
| CHEMBL419534 | — | — | 1 | 6.52 |
| CHEMBL100391 | — | — | 1 | 6.30 |
| CHEMBL430507 | — | — | 1 | 6.16 |
| CHEMBL101311 | — | — | 1 | 6.00 |
| CHEMBL101810 | — | — | 1 | 6.00 |
| CHEMBL322019 | — | — | 1 | 5.70 |
| CHEMBL101468 | — | — | 1 | 5.70 |
| CHEMBL101156 | — | — | 1 | 5.52 |
| CHEMBL99689 | — | — | 1 | 5.40 |
| CHEMBL99948 | — | — | 1 | 5.30 |
| CHEMBL317629 | — | — | 1 | 5.30 |
| CHEMBL101679 | — | — | 1 | 5.22 |
| CHEMBL101019 | — | — | 1 | 5.16 |
| CHEMBL103633 | — | — | 1 | 5.16 |
| CHEMBL101473 | — | — | 1 | 5.10 |
| CHEMBL101887 | — | — | 1 | 4.92 |
| CHEMBL100664 | — | — | 1 | 4.82 |
| CHEMBL430854 | — | — | 1 | 4.75 |
| CHEMBL322640 | — | — | 1 | 4.66 |
| CHEMBL100675 | — | — | 1 | 4.66 |
| CHEMBL99687 | — | — | 1 | 4.58 |
| CHEMBL100811 | — | — | 1 | 4.55 |
| CHEMBL102047 | — | — | 1 | 4.47 |
| CHEMBL101557 | — | — | 1 | 4.46 |
| CHEMBL101052 | — | — | 1 | 4.44 |
| CHEMBL328623 | — | — | 1 | 4.09 |
| CHEMBL101868 | — | — | 1 | 4.07 |
| CHEMBL99647 | — | — | 1 | 4.02 |
| CHEMBL101779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419720 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL419534 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL100391 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL430507 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL101311 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL101810 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL322019 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL101468 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL101156 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL99689 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL99948 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL317629 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL101679 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL101019 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL103633 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL101473 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL101887 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL100664 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL430854 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL100675 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL322640 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL99687 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL100811 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL102047 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL101557 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL101052 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL328623 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL101868 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL99647 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL101779 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL98335 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL102136 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL318485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL318188 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL102008 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL318461 | — | IC50 | > | 100000.0 | nM | - |