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Assay Detail

CHEMBL660785

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Binding
Inhibitory concentration against cyclin-dependent kinase 2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cyclin-dependent kinase 2 (CHEMBL301)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors.
Byth KF, Culshaw JD, Green S, Oakes SE, Thomas AP.
Bioorg Med Chem Lett (2004) 14 : 2245 -2248
PubMed 15081017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.28 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73243 1 8.40
CHEMBL72548 1 8.30
CHEMBL72509 1 8.30
CHEMBL70824 1 8.30
CHEMBL309573 1 7.92
CHEMBL307808 1 7.80
CHEMBL72510 1 7.42
CHEMBL73189 1 6.82
CHEMBL72461 1 6.68
CHEMBL73645 1 6.21
CHEMBL74680 1 6.17
CHEMBL308848 1 5.06
CHEMBL419634 1 -
CHEMBL308853 1 -
CHEMBL70808 1 -
CHEMBL72893 1 -
CHEMBL73038 1 -
CHEMBL71044 1 -
CHEMBL73214 1 -
CHEMBL73303 1 -
CHEMBL72464 1 -
CHEMBL72672 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73243 IC50 = 4.0 nM 8.40
CHEMBL72548 IC50 = 5.0 nM 8.30
CHEMBL72509 IC50 = 5.0 nM 8.30
CHEMBL70824 IC50 = 5.0 nM 8.30
CHEMBL309573 IC50 = 12.0 nM 7.92
CHEMBL307808 IC50 = 16.0 nM 7.80
CHEMBL72510 IC50 = 38.0 nM 7.42
CHEMBL73189 IC50 = 150.0 nM 6.82
CHEMBL72461 IC50 = 210.0 nM 6.68
CHEMBL73645 IC50 = 620.0 nM 6.21
CHEMBL74680 IC50 = 680.0 nM 6.17
CHEMBL308848 IC50 = 8800.0 nM 5.06
CHEMBL419634 IC50 < 3.0 nM -
CHEMBL308853 IC50 < 3.0 nM -
CHEMBL70808 IC50 < 3.0 nM -
CHEMBL72893 IC50 > 10000.0 nM -
CHEMBL73038 IC50 < 3.0 nM -
CHEMBL71044 IC50 < 3.0 nM -
CHEMBL73214 IC50 < 3.0 nM -
CHEMBL73303 IC50 < 3.0 nM -
CHEMBL72464 IC50 < 3.0 nM -
CHEMBL72672 IC50 < 3.0 nM -