Assay Detail
Binding
CHEMBL660787
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Inhibition of Cyclin-dependent kinase 2 (CDK2)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.76 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48362 | — | — | 1 | 7.52 |
| CHEMBL45477 | — | — | 1 | 6.51 |
| CHEMBL112582 | — | — | 1 | 5.97 |
| CHEMBL51709 | — | — | 1 | 5.89 |
| CHEMBL113544 | — | — | 1 | 5.68 |
| CHEMBL326275 | — | — | 1 | 5.68 |
| CHEMBL326843 | — | — | 1 | 5.41 |
| CHEMBL48614 | — | — | 1 | 5.40 |
| CHEMBL112050 | — | — | 1 | 5.18 |
| CHEMBL323015 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48362 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL45477 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL112582 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL51709 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL113544 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL326275 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL326843 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL48614 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL112050 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL323015 | — | IC50 | = | 40400.0 | nM | 4.39 |