Assay Detail
Binding
CHEMBL660796
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Inhibition of Cyclin-dependent kinase 1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.99 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83320 | — | — | 1 | 8.00 |
| CHEMBL84944 | — | — | 1 | 7.00 |
| CHEMBL84436 | — | — | 1 | 5.96 |
| CHEMBL83980 | BOHEMINE | — | 1 | 5.60 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.34 |
| CHEMBL86066 | — | — | 1 | 5.03 |
| CHEMBL84140 | — | — | 1 | 5.00 |
| CHEMBL83719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83320 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL84944 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL84436 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL83980 | BOHEMINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL86066 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL84140 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL83719 | — | IC50 | > | 100000.0 | nM | - |