Assay Detail
Binding
CHEMBL660800
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Inhibition of Cyclin-dependent kinase 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.63 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | — | 1 | 5.90 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | — | 1 | 5.35 |
| CHEMBL340776 | — | — | 1 | - |
| CHEMBL337642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340259 | INDOLYLYLMALEIMIDE 2 | IC50 | = | 1251.0 | nM | 5.90 |
| CHEMBL340935 | INDOLYLYLMALEIMIDE 1 | IC50 | = | 4428.0 | nM | 5.35 |
| CHEMBL340776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337642 | — | IC50 | > | 10000.0 | nM | - |