Assay Detail
Binding
CHEMBL660857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition against [3H]cocaine binding to cocaine receptor in bovine striatal tissue
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.52 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790051 | — | — | 2 | 7.66 |
| CHEMBL60609 | — | — | 2 | 6.86 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.86 |
| CHEMBL302855 | — | — | 1 | 6.72 |
| CHEMBL62608 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790051 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL60609 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL370805 | COCAINE | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL302855 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL60609 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL1790051 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL62608 | — | IC50 | = | 11000.0 | nM | 4.96 |