Assay Detail
Binding
CHEMBL660914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]ouabain binding to Na/K ATP-ase in dog heart muscle
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Muscle tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Sodium/potassium-transporting ATPase (CHEMBL2095186) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Pregnanes that bind to the digitalis receptor: synthesis of 14-hydroxy-5 beta,14 beta-pregnane glycosides from digitoxin and digitoxigenin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.67 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2092909 | — | — | 1 | 8.52 |
| CHEMBL2092738 | — | — | 1 | 8.15 |
| CHEMBL3085467 | — | — | 1 | 8.10 |
| CHEMBL3085497 | — | — | 1 | 8.10 |
| CHEMBL3085468 | — | — | 1 | 8.05 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 7.70 |
| CHEMBL3085496 | — | — | 1 | 7.16 |
| CHEMBL2092910 | — | — | 1 | 7.12 |
| CHEMBL2092911 | — | — | 1 | 6.82 |
| CHEMBL2092826 | — | — | 1 | 6.40 |
| CHEMBL2092827 | — | — | 1 | 6.30 |
| CHEMBL3085471 | — | — | 1 | 6.19 |
| CHEMBL3085500 | — | — | 1 | 6.19 |
| CHEMBL3085469 | — | — | 1 | 6.19 |
| CHEMBL3085501 | — | — | 1 | 6.10 |
| CHEMBL3085470 | — | — | 1 | 6.00 |
| CHEMBL3085502 | — | — | 1 | 5.89 |
| CHEMBL3085578 | — | — | 1 | 5.19 |
| CHEMBL3085579 | — | — | 1 | 4.70 |
| CHEMBL3085498 | — | — | 1 | 4.62 |
| CHEMBL3085499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2092909 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2092738 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3085467 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3085497 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3085468 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1453 | DIGITOXIGENIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3085496 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2092910 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2092911 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2092826 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2092827 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3085471 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3085500 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3085469 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3085501 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3085470 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3085502 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3085578 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3085579 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3085498 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3085499 | — | IC50 | > | 200000.0 | nM | - |