Assay Detail
Binding
CHEMBL660979
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Ability to displace ethidium bromide from calf thymus DNA
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Synthesis and DNA-binding properties of polyamine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.01 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80874 | — | — | 1 | 5.42 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 5.37 |
| CHEMBL28489 | — | — | 1 | 5.31 |
| CHEMBL80188 | — | — | 1 | 5.31 |
| CHEMBL78613 | — | — | 1 | 5.30 |
| CHEMBL78670 | — | — | 1 | 5.28 |
| CHEMBL78409 | — | — | 1 | 5.26 |
| CHEMBL40258 | — | — | 1 | 5.22 |
| CHEMBL81822 | — | — | 1 | 5.22 |
| CHEMBL28192 | — | — | 1 | 5.22 |
| CHEMBL80511 | — | — | 1 | 5.19 |
| CHEMBL29818 | — | — | 1 | 5.16 |
| CHEMBL79044 | — | — | 1 | 5.12 |
| CHEMBL29283 | — | — | 1 | 5.12 |
| CHEMBL78612 | — | — | 1 | 5.12 |
| CHEMBL81759 | — | — | 1 | 5.10 |
| CHEMBL78198 | — | — | 1 | 5.10 |
| CHEMBL80796 | — | — | 1 | 5.10 |
| CHEMBL79047 | — | — | 1 | 5.09 |
| CHEMBL81614 | — | — | 1 | 5.00 |
| CHEMBL80313 | — | — | 1 | 5.00 |
| CHEMBL81075 | — | — | 1 | 5.00 |
| CHEMBL81149 | — | — | 1 | 4.96 |
| CHEMBL82549 | — | — | 1 | 4.92 |
| CHEMBL80480 | — | — | 1 | 4.92 |
| CHEMBL82252 | — | — | 1 | 4.92 |
| CHEMBL81422 | — | — | 1 | 4.92 |
| CHEMBL79172 | — | — | 1 | 4.92 |
| CHEMBL439761 | — | — | 1 | 4.89 |
| CHEMBL29142 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80874 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL23194 | SPERMINE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL80188 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL28489 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL78613 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL78670 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL78409 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL28192 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL40258 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL81822 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL80511 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL29818 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL78612 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL29283 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL79044 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL81759 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL80796 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL78198 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL79047 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL81614 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL80313 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL81075 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL81149 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL79172 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL81422 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL82252 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL82549 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL80480 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL439761 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL29142 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL27909 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL284417 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL422415 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL27912 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL78246 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL420586 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL81825 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL28743 | NORSPERMIDINE | IC50 | = | 220000.0 | nM | - |
| CHEMBL312505 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL79630 | — | IC50 | = | 875000.0 | nM | - |
| CHEMBL28866 | — | IC50 | = | 1450000.0 | nM | - |
| CHEMBL82255 | — | IC50 | = | 600000.0 | nM | - |
| CHEMBL82254 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL19612 | SPERMIDINE | IC50 | = | 130000.0 | nM | - |
| CHEMBL79069 | — | IC50 | = | 600000.0 | nM | - |
| CHEMBL311081 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL80850 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL81145 | — | IC50 | = | 800000.0 | nM | - |
| CHEMBL46257 | PUTRESCINE | IC50 | = | 4500000.0 | nM | - |
| CHEMBL77442 | — | IC50 | = | 275000.0 | nM | - |