Assay Detail
Binding
CHEMBL660981
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Concentration required to decrease the fluorescence of the ethidium bromide-calf thymus DNA complex by 50%
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of boron-containing polyamines as potential agents for neutron capture therapy of brain tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.97 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 5.52 |
| CHEMBL3559420 | — | — | 1 | 5.42 |
| CHEMBL3559422 | — | — | 1 | 5.40 |
| CHEMBL3559418 | — | — | 1 | 4.66 |
| CHEMBL3559421 | — | — | 1 | 4.64 |
| CHEMBL3559419 | — | — | 1 | 4.18 |
| CHEMBL2448385 | — | — | 1 | - |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | - |
| CHEMBL283587 | N1-(3-Amino-propyl)-N1-(4-cyclopropyl-butyl)-butane-1,4-diamine(B10H10) | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23194 | SPERMINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3559420 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3559422 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3559418 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL3559421 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3559419 | — | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL2448385 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL19612 | SPERMIDINE | IC50 | = | 105000.0 | nM | - |
| CHEMBL283587 | N1-(3-Amino-propyl)-N1-(4-cyclopropyl-butyl)-butane-1,4-diamine(B10H10) | IC50 | = | 147000.0 | nM | - |