Assay Detail
Functional
CHEMBL660984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase alpha catalytic subunit (CHEMBL1828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.21 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51613 | — | — | 1 | 4.34 |
| CHEMBL53605 | — | — | 1 | 4.07 |
| CHEMBL53912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51613 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL53605 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL53912 | — | IC50 | > | 1000000.0 | nM | - |