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Assay Detail

CHEMBL661022

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against human cathepsin E
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cathepsin E (CHEMBL3092)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.
Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM.
J Med Chem (1993) 36 : 2614 -2620
PubMed 8410973 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.15 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL313773 1 10.00
CHEMBL88415 1 9.30
CHEMBL287423 1 9.30
CHEMBL84970 1 8.70
CHEMBL87025 1 8.66
CHEMBL88526 1 8.54
CHEMBL88356 1 8.48
CHEMBL316095 1 7.96
CHEMBL418948 1 7.82
CHEMBL62380 1 7.77
CHEMBL88340 1 7.68
CHEMBL329220 1 7.36
CHEMBL88654 1 6.52
CHEMBL3348525 1 6.07
CHEMBL90683 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL313773 Ki = 0.1 nM 10.00
CHEMBL88415 Ki = 0.5 nM 9.30
CHEMBL287423 Ki = 0.5 nM 9.30
CHEMBL84970 Ki = 2.0 nM 8.70
CHEMBL87025 Ki = 2.2 nM 8.66
CHEMBL88526 Ki = 2.9 nM 8.54
CHEMBL88356 Ki = 3.3 nM 8.48
CHEMBL316095 Ki = 11.0 nM 7.96
CHEMBL418948 Ki = 15.0 nM 7.82
CHEMBL62380 Ki = 17.0 nM 7.77
CHEMBL88340 Ki = 21.0 nM 7.68
CHEMBL329220 Ki = 44.0 nM 7.36
CHEMBL88654 Ki = 300.0 nM 6.52
CHEMBL3348525 Ki = 850.0 nM 6.07
CHEMBL90683 Ki > 10000.0 nM -