Assay Detail
Binding
CHEMBL661099
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In vitro inhibition of Catechol-O-methyltransferase (COMT) from isolated partially purified pig liver enzyme
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dihydroxynitrobenzaldehydes and hydroxymethoxynitrobenzaldehydes: synthesis and biological activity as catechol-O-methyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.37 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357072 | — | — | 1 | 5.82 |
| CHEMBL139882 | — | — | 1 | 5.82 |
| CHEMBL1244 | 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | — | 1 | 5.70 |
| CHEMBL141858 | — | — | 1 | 5.68 |
| CHEMBL142876 | — | — | 1 | 5.07 |
| CHEMBL334706 | — | — | 1 | 5.00 |
| CHEMBL89320 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357072 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL139882 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1244 | 3,4-DIHYDROXY-5-NITROBENZALDEHYDE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL141858 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL142876 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL334706 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL89320 | — | IC50 | = | 34000.0 | nM | 4.47 |