Assay Detail
Binding
CHEMBL661124
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Evaluated for inhibition of human cyclin dependent kinase 2 (CDK2)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
General model for estimation of the inhibition of protein kinases using Monte Carlo simulations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.45 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409731 | — | — | 1 | 8.68 |
| CHEMBL1794055 | GW589933X | — | 1 | 8.55 |
| CHEMBL1964244 | — | — | 1 | 8.37 |
| CHEMBL272667 | — | — | 1 | 8.34 |
| CHEMBL1964247 | — | — | 1 | 8.34 |
| CHEMBL1964246 | — | — | 1 | 8.33 |
| CHEMBL1964242 | — | — | 1 | 8.25 |
| CHEMBL1964245 | — | — | 1 | 8.25 |
| CHEMBL1276446 | — | — | 1 | 8.01 |
| CHEMBL411490 | — | — | 1 | 7.89 |
| CHEMBL412097 | — | — | 1 | 7.66 |
| CHEMBL48362 | — | — | 1 | 7.52 |
| CHEMBL271137 | — | — | 1 | 7.27 |
| CHEMBL271822 | — | — | 1 | 7.27 |
| CHEMBL410293 | — | — | 1 | 7.21 |
| CHEMBL1964243 | — | — | 1 | 7.12 |
| CHEMBL272414 | GW416469X | — | 1 | 6.51 |
| CHEMBL45477 | — | — | 1 | 6.51 |
| CHEMBL405042 | GW335962X | — | 1 | 6.44 |
| CHEMBL269850 | — | — | 1 | 6.16 |
| CHEMBL51709 | — | — | 1 | 5.89 |
| CHEMBL48614 | — | — | 1 | 5.40 |
| CHEMBL408131 | — | — | 1 | - |
| CHEMBL410517 | — | — | 1 | - |
| CHEMBL314877 | — | — | 1 | - |
| CHEMBL87527 | — | — | 1 | - |
| CHEMBL85450 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409731 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1794055 | GW589933X | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1964244 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL272667 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1964247 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1964246 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1964242 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1964245 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1276446 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL411490 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL412097 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL48362 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL271137 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL271822 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL410293 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1964243 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL272414 | GW416469X | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL45477 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL405042 | GW335962X | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL269850 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL51709 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL48614 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL408131 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL314877 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL87527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL85450 | — | IC50 | > | 10000.0 | nM | - |