Assay Detail
Binding
CHEMBL661129
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In vitro inhibition of Cyclin-dependent kinase 2 was determined.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and X-ray crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.55 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317703 | — | — | 1 | 9.48 |
| CHEMBL321517 | — | — | 1 | 9.47 |
| CHEMBL103104 | GW831090X | — | 1 | 8.04 |
| CHEMBL319903 | — | — | 1 | 8.00 |
| CHEMBL421578 | — | — | 1 | 7.97 |
| CHEMBL319103 | — | — | 1 | 7.97 |
| CHEMBL103115 | GW831091X | — | 1 | 7.90 |
| CHEMBL103382 | — | — | 1 | 7.76 |
| CHEMBL103285 | — | — | 1 | 7.63 |
| CHEMBL319685 | — | — | 1 | 7.61 |
| CHEMBL321939 | — | — | 1 | 7.21 |
| CHEMBL319831 | — | — | 1 | 6.78 |
| CHEMBL102241 | — | — | 1 | 6.39 |
| CHEMBL103039 | — | — | 1 | 6.31 |
| CHEMBL418985 | — | — | 1 | 6.22 |
| CHEMBL329040 | — | — | 1 | 6.06 |
| CHEMBL323326 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317703 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL321517 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL103104 | GW831090X | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL319903 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL421578 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL319103 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL103115 | GW831091X | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL103382 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL103285 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL319685 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL321939 | — | IC50 | = | 61.6 | nM | 7.21 |
| CHEMBL319831 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL102241 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL103039 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL418985 | — | IC50 | = | 602.0 | nM | 6.22 |
| CHEMBL329040 | — | IC50 | = | 871.0 | nM | 6.06 |
| CHEMBL323326 | — | IC50 | > | 2000.0 | nM | - |