Assay Detail
Binding
CHEMBL661130
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Inhibition of Cyclin-dependent kinase 2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.05 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84944 | — | — | 1 | 7.52 |
| CHEMBL84436 | — | — | 1 | 6.70 |
| CHEMBL83980 | BOHEMINE | — | 1 | 6.10 |
| CHEMBL315837 | — | — | 1 | 6.05 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.92 |
| CHEMBL84140 | — | — | 1 | 5.62 |
| CHEMBL85015 | — | — | 1 | 5.35 |
| CHEMBL86066 | — | — | 1 | 5.10 |
| CHEMBL83719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84944 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL84436 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL83980 | BOHEMINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL315837 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL84140 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL85015 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL86066 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL83719 | — | IC50 | > | 100000.0 | nM | - |