Assay Detail
Binding
CHEMBL661164
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In vitro inhibition of [125I]CCK-8 binding to guinea pig pancreas
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
CCK-A-selective tetrapeptides containing lys(N epsilon)-amide residues: favorable in vivo and in vitro effects of N-methylation at the aspartyl residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.84 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156559 | — | — | 1 | 8.43 |
| CHEMBL411466 | — | — | 1 | 8.38 |
| CHEMBL290936 | — | — | 1 | 8.30 |
| CHEMBL432293 | — | — | 1 | 8.05 |
| CHEMBL290143 | — | — | 1 | 7.75 |
| CHEMBL290034 | — | — | 1 | 7.50 |
| CHEMBL290142 | — | — | 1 | 7.46 |
| CHEMBL289744 | — | — | 1 | 7.39 |
| CHEMBL289284 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156559 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL411466 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL290936 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL432293 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL290143 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL290034 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL290142 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL289744 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL289284 | — | IC50 | = | 50.0 | nM | 7.30 |