Assay Detail
Functional
CHEMBL661165
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Inhibitory activity against prostaglandin biosynthesis in stimulated chondrocyte cell culture
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.28 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71280 | — | — | 1 | 7.96 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.96 |
| CHEMBL440683 | — | — | 1 | 7.82 |
| CHEMBL70331 | — | — | 1 | 7.82 |
| CHEMBL417744 | — | — | 1 | 7.70 |
| CHEMBL430916 | DEXPEMEDOLAC | 2.0 | 1 | 7.64 |
| CHEMBL622 | ETODOLAC | 4.0 | 1 | 7.64 |
| CHEMBL67817 | — | — | 1 | 7.30 |
| CHEMBL68102 | — | — | 1 | 7.30 |
| CHEMBL71567 | — | — | 1 | 6.92 |
| CHEMBL73938 | — | — | 1 | 6.70 |
| CHEMBL305523 | — | — | 1 | 6.52 |
| CHEMBL307285 | — | — | 1 | 5.40 |
| CHEMBL70419 | — | — | 1 | - |
| CHEMBL302762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71280 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL440683 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL70331 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL417744 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL430916 | DEXPEMEDOLAC | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL622 | ETODOLAC | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL67817 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL68102 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL71567 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL73938 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL305523 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL307285 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL70419 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL302762 | — | IC50 | > | 10000.0 | nM | - |