Assay Detail
Binding
CHEMBL661233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity in pancreatic cholecystokinin type A receptor in guinea pig
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.48 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64605 | — | — | 1 | 5.75 |
| CHEMBL2370879 | — | — | 1 | 5.68 |
| CHEMBL3143186 | — | — | 1 | 5.57 |
| CHEMBL169054 | — | — | 1 | 5.40 |
| CHEMBL333299 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64605 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2370879 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3143186 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL169054 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL333299 | — | IC50 | = | 10300.0 | nM | 4.99 |