Assay Detail
Binding
CHEMBL661267
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Compound was evaluated for inhibitory activity against Bovine Chymotrypsinogen
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.93 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355430 | — | — | 1 | 7.47 |
| CHEMBL169707 | — | — | 1 | 6.44 |
| CHEMBL433799 | — | — | 1 | 6.32 |
| CHEMBL171769 | — | — | 1 | 5.99 |
| CHEMBL366721 | — | — | 1 | 5.91 |
| CHEMBL436061 | — | — | 1 | 5.89 |
| CHEMBL170697 | — | — | 1 | 5.40 |
| CHEMBL170152 | — | — | 1 | 4.03 |
| CHEMBL367094 | — | — | 1 | - |
| CHEMBL355132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355430 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL169707 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL433799 | — | Ki | = | 476.0 | nM | 6.32 |
| CHEMBL171769 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL366721 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL436061 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL170697 | — | Ki | = | 3950.0 | nM | 5.40 |
| CHEMBL170152 | — | Ki | = | 92900.0 | nM | 4.03 |
| CHEMBL367094 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL355132 | — | Ki | > | 100000.0 | nM | - |