Assay Detail
Functional
CHEMBL661326
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Evaluated in vitro for its ability to inhibit prostaglandin E2 production in cultured chondrocyte cells at 25 mg/kg dose
6
Total Activities
6
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.96 | 7.60 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| DOSE | DOSE | 25.0 | mg.kg-1 | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL622 | ETODOLAC | 4.0 | 1 | 7.60 |
| CHEMBL296550 | — | — | 1 | 6.73 |
| CHEMBL874 | 8-(1-HYDROXYETHYL)ETODOLAC | — | 1 | 5.70 |
| CHEMBL873 | 6-HYDROXYETODOLAC | — | 1 | 5.19 |
| CHEMBL45545 | — | — | 1 | 4.60 |
| CHEMBL872 | 4-UREIDOETODOLAC | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL622 | ETODOLAC | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL296550 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL874 | 8-(1-HYDROXYETHYL)ETODOLAC | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL873 | 6-HYDROXYETODOLAC | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL45545 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL872 | 4-UREIDOETODOLAC | IC50 | > | 100000.0 | nM | - |