Assay Detail
Binding
CHEMBL661336
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Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cells
58
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 58 | 7.66 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105821 | — | — | 1 | 8.96 |
| CHEMBL323172 | — | — | 1 | 8.96 |
| CHEMBL324643 | — | — | 1 | 8.70 |
| CHEMBL324671 | — | — | 2 | 8.70 |
| CHEMBL78535 | ANCRIVIROC | 2.0 | 1 | 8.68 |
| CHEMBL321413 | — | — | 1 | 8.52 |
| CHEMBL105784 | — | — | 1 | 8.47 |
| CHEMBL106533 | — | — | 1 | 8.42 |
| CHEMBL109008 | — | — | 1 | 8.40 |
| CHEMBL318311 | — | — | 1 | 8.36 |
| CHEMBL109158 | — | — | 1 | 8.35 |
| CHEMBL320502 | — | — | 1 | 8.28 |
| CHEMBL419735 | — | — | 1 | 8.25 |
| CHEMBL110757 | — | — | 1 | 8.15 |
| CHEMBL106813 | — | — | 1 | 8.12 |
| CHEMBL107154 | — | — | 1 | 8.10 |
| CHEMBL418997 | — | — | 1 | 8.05 |
| CHEMBL107363 | — | — | 1 | 7.92 |
| CHEMBL317644 | — | — | 1 | 7.80 |
| CHEMBL106767 | — | — | 1 | 7.75 |
| CHEMBL106098 | — | — | 1 | 7.72 |
| CHEMBL106558 | — | — | 1 | 7.70 |
| CHEMBL106099 | — | — | 1 | 7.62 |
| CHEMBL107092 | — | — | 1 | 7.60 |
| CHEMBL112760 | — | — | 1 | 7.60 |
| CHEMBL443999 | — | — | 1 | 7.58 |
| CHEMBL108569 | — | — | 1 | 7.54 |
| CHEMBL107999 | — | — | 1 | 7.52 |
| CHEMBL432636 | — | — | 1 | 7.52 |
| CHEMBL105779 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105821 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL323172 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL324671 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL324643 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL78535 | ANCRIVIROC | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL321413 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL105784 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL106533 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL109008 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL318311 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL109158 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL320502 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL419735 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL110757 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL106813 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL107154 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL418997 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL324671 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL107363 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL317644 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL106767 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL106098 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL106558 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL106099 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL112760 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL107092 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL443999 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL108569 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL107999 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL432636 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL105779 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL106790 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL106406 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL106982 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL110730 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL331140 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL106209 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL317476 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL106247 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL106507 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL110871 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL110809 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL106299 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL106468 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL110463 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL110786 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL106369 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL323454 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL110270 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL106264 | — | Ki | = | 363.0 | nM | 6.44 |