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Assay Detail

CHEMBL661429

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro apparent inhibition constant of porcine renal Dehydropeptidase-1.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dipeptidase 1 (CHEMBL2626)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.
Toney JH, Cleary KA, Hammond GG, Yuan X, May WJ, Hutchins SM, Ashton WT, Vanderwall DE.
Bioorg Med Chem Lett (1999) 9 : 2741 -2746
PubMed 10509927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 4.10 4.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329541 1 4.10
CHEMBL90774 1 -
CHEMBL91287 1 -
CHEMBL93289 1 -
CHEMBL93886 1 -
CHEMBL328598 1 -
CHEMBL92654 1 -
CHEMBL315878 1 -
CHEMBL93547 1 -
CHEMBL94002 1 -
CHEMBL94221 1 -
CHEMBL92821 1 -
CHEMBL329466 1 -
CHEMBL419321 1 -
CHEMBL92472 1 -
CHEMBL329616 1 -
CHEMBL327837 1 -
CHEMBL90011 1 -
CHEMBL330571 1 -
CHEMBL327982 1 -
CHEMBL93226 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329541 Ki = 80000.0 nM 4.10
CHEMBL90774 Ki = 800000.0 nM -
CHEMBL91287 Ki = 380000.0 nM -
CHEMBL93289 Ki = 450000.0 nM -
CHEMBL93886 Ki = 420000.0 nM -
CHEMBL328598 Ki = 450000.0 nM -
CHEMBL92654 Ki = 380000.0 nM -
CHEMBL315878 Ki = 380000.0 nM -
CHEMBL93547 Ki = 640000.0 nM -
CHEMBL94002 Ki = 310000.0 nM -
CHEMBL94221 Ki = 430000.0 nM -
CHEMBL92821 Ki = 250000.0 nM -
CHEMBL329466 Ki = 250000.0 nM -
CHEMBL419321 Ki = 170000.0 nM -
CHEMBL92472 Ki = 400000.0 nM -
CHEMBL329616 Ki = 500000.0 nM -
CHEMBL327837 Ki = 480000.0 nM -
CHEMBL90011 Ki = 470000.0 nM -
CHEMBL330571 Ki = 425000.0 nM -
CHEMBL327982 Ki = 590000.0 nM -
CHEMBL93226 Ki = 350000.0 nM -