Assay Detail
Binding
CHEMBL661439
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Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.75 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.64 |
| CHEMBL88545 | — | — | 1 | 6.75 |
| CHEMBL293226 | — | — | 1 | 6.00 |
| CHEMBL310466 | — | — | 1 | 5.62 |
| CHEMBL430451 | — | — | 1 | 5.58 |
| CHEMBL88602 | — | — | 1 | 5.28 |
| CHEMBL316164 | — | — | 1 | 4.76 |
| CHEMBL88629 | — | — | 1 | 4.16 |
| CHEMBL89953 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 0.2291 | nM | 9.64 |
| CHEMBL88545 | — | IC50 | = | 177.83 | nM | 6.75 |
| CHEMBL293226 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL310466 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL430451 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL88602 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL316164 | — | IC50 | = | 17378.01 | nM | 4.76 |
| CHEMBL88629 | — | IC50 | = | 69183.1 | nM | 4.16 |
| CHEMBL89953 | — | IC50 | = | 100000.0 | nM | 4.00 |