Assay Detail
Binding
CHEMBL661623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclin B activated Cyclin-dependent kinase 1 (CDK1)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.93 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48362 | — | — | 1 | 8.05 |
| CHEMBL45477 | — | — | 1 | 7.22 |
| CHEMBL418203 | — | — | 1 | 7.00 |
| CHEMBL51709 | — | — | 1 | 6.96 |
| CHEMBL48614 | — | — | 1 | 6.22 |
| CHEMBL46181 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48362 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL45477 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL418203 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL51709 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL48614 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL46181 | — | IC50 | = | 800.0 | nM | 6.10 |