Assay Detail
Binding
CHEMBL661701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [1-beta-3H]-androstenedione binding to Cytochrome P450 19A1 of JEG-3 human placental carcinoma cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
First dual aromatase-steroid sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.46 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108425 | — | — | 1 | 9.30 |
| CHEMBL108483 | — | — | 1 | 9.09 |
| CHEMBL430879 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108425 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL108483 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL430879 | — | IC50 | = | 100.0 | nM | 7.00 |