Assay Detail
Binding
CHEMBL661735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-KI |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.84 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.20 |
| CHEMBL358778 | — | — | 1 | 8.00 |
| CHEMBL356408 | — | — | 1 | 7.80 |
| CHEMBL321761 | — | — | 1 | 7.30 |
| CHEMBL147186 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL358778 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL356408 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL321761 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL147186 | — | IC50 | = | 125.89 | nM | 6.90 |