Assay Detail
Binding
CHEMBL661740
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In vitro for binding affinity against human cholecystokinin type A receptor.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.23 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 8.88 |
| CHEMBL316164 | — | — | 1 | 8.08 |
| CHEMBL88602 | — | — | 1 | 7.97 |
| CHEMBL88629 | — | — | 1 | 7.88 |
| CHEMBL328285 | — | — | 1 | 7.86 |
| CHEMBL327815 | — | — | 1 | 7.84 |
| CHEMBL327849 | — | — | 1 | 7.77 |
| CHEMBL328586 | — | — | 1 | 7.76 |
| CHEMBL327909 | — | — | 1 | 7.75 |
| CHEMBL406790 | — | — | 1 | 7.68 |
| CHEMBL293226 | — | — | 1 | 7.64 |
| CHEMBL90697 | — | — | 1 | 7.53 |
| CHEMBL316104 | — | — | 1 | 7.41 |
| CHEMBL310466 | — | — | 1 | 7.37 |
| CHEMBL94005 | — | — | 1 | 7.37 |
| CHEMBL88545 | — | — | 1 | 7.06 |
| CHEMBL91986 | — | — | 1 | 7.05 |
| CHEMBL327656 | — | — | 1 | 6.95 |
| CHEMBL316077 | — | — | 1 | 6.89 |
| CHEMBL330521 | — | — | 1 | 6.86 |
| CHEMBL89953 | — | — | 1 | 6.51 |
| CHEMBL316106 | — | — | 1 | 6.45 |
| CHEMBL92586 | — | — | 1 | 6.32 |
| CHEMBL330566 | — | — | 1 | 6.28 |
| CHEMBL327552 | — | — | 1 | 6.18 |
| CHEMBL431451 | — | — | 1 | 6.05 |
| CHEMBL329407 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 1.318 | nM | 8.88 |
| CHEMBL316164 | — | IC50 | = | 8.318 | nM | 8.08 |
| CHEMBL88602 | — | IC50 | = | 10.81 | nM | 7.97 |
| CHEMBL88629 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL328285 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL327815 | — | IC50 | = | 14.45 | nM | 7.84 |
| CHEMBL327849 | — | IC50 | = | 16.98 | nM | 7.77 |
| CHEMBL328586 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL327909 | — | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL406790 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL293226 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL90697 | — | IC50 | = | 29.51 | nM | 7.53 |
| CHEMBL316104 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL310466 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL94005 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL88545 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL91986 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL327656 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL316077 | — | IC50 | = | 128.82 | nM | 6.89 |
| CHEMBL330521 | — | IC50 | = | 138.04 | nM | 6.86 |
| CHEMBL89953 | — | IC50 | = | 309.03 | nM | 6.51 |
| CHEMBL316106 | — | IC50 | = | 354.81 | nM | 6.45 |
| CHEMBL92586 | — | IC50 | = | 478.63 | nM | 6.32 |
| CHEMBL330566 | — | IC50 | = | 524.81 | nM | 6.28 |
| CHEMBL327552 | — | IC50 | = | 660.69 | nM | 6.18 |
| CHEMBL431451 | — | IC50 | = | 891.25 | nM | 6.05 |
| CHEMBL329407 | — | IC50 | = | 1584.89 | nM | 5.80 |